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Relationship between impaired myocardial blood flow by positron emission tomography and low-attenuation plaque burden and pericoronary adipose tissue attenuation from coronary computed tomography: From the prospective PACIFIC trial.
Kuronuma, Keiichiro; van Diemen, Pepijn A; Han, Donghee; Lin, Andrew; Grodecki, Kajetan; Kwiecinski, Jacek; Motwani, Manish; McElhinney, Priscilla; Tomasino, Guadalupe Flores; Park, Caroline; Kwan, Alan; Tzolos, Evangelos; Klein, Eyal; Shou, Benjamin; Tamarappoo, Balaji; Cadet, Sebastien; Danad, Ibrahim; Driessen, Roel S; Berman, Daniel S; Slomka, Piotr J; Dey, Damini; Knaapen, Paul.
Afiliação
  • Kuronuma K; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • van Diemen PA; Department of Cardiology, Nihon University, Tokyo, Japan.
  • Han D; Department of Cardiology, Amsterdam UMC, VUmc, Amsterdam, The Netherlands.
  • Lin A; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Grodecki K; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Kwiecinski J; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Motwani M; Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
  • McElhinney P; Manchester Heart Centre, Manchester University NHS Foundation Trust, Manchester, UK.
  • Tomasino GF; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Park C; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Kwan A; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Tzolos E; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Klein E; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
  • Shou B; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Tamarappoo B; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Cadet S; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Danad I; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA.
  • Driessen RS; Department of Cardiology, Amsterdam UMC, VUmc, Amsterdam, The Netherlands.
  • Berman DS; Department of Cardiology, Amsterdam UMC, VUmc, Amsterdam, The Netherlands.
  • Slomka PJ; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Dey D; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Knaapen P; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Boulevard, Los Angeles, CA, 90048, USA. damini.dey@cshs.org.
J Nucl Cardiol ; 30(4): 1558-1569, 2023 08.
Article em En | MEDLINE | ID: mdl-36645580
ABSTRACT

BACKGROUND:

Positron emission tomography (PET) is the clinical gold standard for quantifying myocardial blood flow (MBF). Pericoronary adipose tissue (PCAT) attenuation may detect vascular inflammation indirectly. We examined the relationship between MBF by PET and plaque burden and PCAT on coronary CT angiography (CCTA).

METHODS:

This post hoc analysis of the PACIFIC trial included 208 patients with suspected coronary artery disease (CAD) who underwent [15O]H2O PET and CCTA. Low-attenuation plaque (LAP, < 30HU), non-calcified plaque (NCP), and PCAT attenuation were measured by CCTA.

RESULTS:

In 582 vessels, 211 (36.3%) had impaired per-vessel hyperemic MBF (≤ 2.30 mL/min/g). In multivariable analysis, LAP burden was independently and consistently associated with impaired hyperemic MBF (P = 0.016); over NCP burden (P = 0.997). Addition of LAP burden improved predictive performance for impaired hyperemic MBF from a model with CAD severity and calcified plaque burden (P < 0.001). There was no correlation between PCAT attenuation and hyperemic MBF (r = - 0.11), and PCAT attenuation was not associated with impaired hyperemic MBF in univariable or multivariable analysis of all vessels (P > 0.1).

CONCLUSION:

In patients with stable CAD, LAP burden was independently associated with impaired hyperemic MBF and a stronger predictor of impaired hyperemic MBF than NCP burden. There was no association between PCAT attenuation and hyperemic MBF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Nucl Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Nucl Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos