Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.

Kong, Sun Ju; Nam, Gibeom; Boggu, Pulla Reddy; Park, Gi Min; Kang, Ji Eun; Park, Hyun-Ju; Jung, Young Hoon

Kong, Sun Ju; Nam, Gibeom; Boggu, Pulla Reddy; Park, Gi Min; Kang, Ji Eun; Park, Hyun-Ju; Jung, Young Hoon.

Afiliação

Kong SJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Nam G; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Boggu PR; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Park GM; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kang JE; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Park HJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Jung YH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: yhjung@skku.edu.

Bioorg Med Chem ; 79: 117154, 2023 02 01.

Article em En | MEDLINE | ID: mdl-36645952

Assuntos

Inibidores de Histona Desacetilases; Histona Desacetilases; Desacetilase 6 de Histona; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/metabolismo; Ácidos Hidroxâmicos/farmacologia; Triazóis/farmacologia; Histona Desacetilase 1

Palavras-chave

Computational docking; HDAC6 inhibitor; N-Benzyltriazolyl hydroxamate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Histona Desacetilases Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article

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