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Linoleic Acid-Enriched Diet Increases Mitochondrial Tetralinoleoyl Cardiolipin, OXPHOS Protein Levels, and Uncoupling in Interscapular Brown Adipose Tissue during Diet-Induced Weight Gain.
Snoke, Deena B; Mahler, Connor A; Angelotti, Austin; Cole, Rachel M; Sparagna, Genevieve C; Baskin, Kedryn K; Belury, Martha A.
Afiliação
  • Snoke DB; Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
  • Mahler CA; Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA.
  • Angelotti A; Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA.
  • Cole RM; Indiana Biosciences Research Institute, Indianapolis, IN 46062, USA.
  • Sparagna GC; Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA.
  • Baskin KK; Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA.
  • Belury MA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Biology (Basel) ; 12(1)2022 Dec 21.
Article em En | MEDLINE | ID: mdl-36671702
ABSTRACT
Cardiolipin (CL) is a phospholipid unique to the inner mitochondrial membrane that supports respiratory chain structure and function and is demonstrated to be influenced by types of dietary fats. However, the influence of dietary fat on CL species and how this best supports mitochondrial function in brown adipose tissue (BAT), which exhibits an alternative method of energy utilization through the uncoupling of the mitochondrial proton gradient to generate heat, is not well understood. Therefore, the aim of our study was to evaluate metabolic parameters, interscapular BAT CL quantity, species, and mitochondrial function in mice consuming isocaloric moderate-fat diets with either lard (LD; similar fatty acid profile to western dietary patterns) or safflower oil high in linoleic acid (SO), shown to be metabolically favorable in large clinical meta-analyses. Mice fed the SO diet exhibited decreased adiposity, improved insulin sensitivity, and enrichment of LA-containing CL species in BAT CL. Furthermore, mice fed the SO diet exhibit higher levels of OXPHOS complex proteins and increased oxygen consumption in BAT. Our findings demonstrate that dietary consumption of LA-rich oil improves metabolic parameters, increases LA-containing CL species, and improves BAT function when compared to the consumption of lard in mice during diet-induced weight gain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biology (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biology (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos