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Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense.
Huang, Jin-Chang; Xu, Hong-Hong; Shi, Qing; Lei, Chun; Li, Jing-Ya; Hou, Ai-Jun.
Afiliação
  • Huang JC; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China; School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China.
  • Xu HH; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • Shi Q; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China; School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China.
  • Lei C; School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China.
  • Li JY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. Electronic address: jyli@simm.ac.cn.
  • Hou AJ; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China; School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China. Electronic address: ajhou@sjtu.edu.cn.
Bioorg Chem ; 132: 106381, 2023 03.
Article em En | MEDLINE | ID: mdl-36706532
ABSTRACT
Two enantiomeric pairs of macrocyclic acylphloroglucinols (1a/1b and 2a/2b) with an unprecedented carbon skeleton featuring a bicyclo[12.3.1]octadecane core, together with an undescribed biogenetically related long-chain acylphloroglucinol (3), were isolated from Syzygium szemaoense. Their structures were fully established by spectroscopic method, X-ray crystallographic analysis, and ECD calculation. Compounds 1b and 2a/2b exhibited inhibition against death-associated protein kinase-related apoptosis inducing protein kinase 2 (DRAK2) and ATP citrate lyase (ACLY), respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Syzygium Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Syzygium Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article