Orally delivered single-domain antibodies against gastrointestinal pathogens.
Trends Biotechnol
; 41(7): 875-886, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-36774206
ABSTRACT
Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulins. They can withstand extreme pH, high temperature, and proteolysis, making them suitable for controlling gastrointestinal (GI) infections in humans and animals. sdAbs may function in their native soluble form, although different derived protein formats and the use of delivery vehicles can be useful for improved oral delivery. We discuss selected examples of the use of orally delivered sdAbs for protecting humans and animals against GI infections caused by pathogenic bacteria, viruses, and parasites. We finally provide perspectives on how sdAbs may be applied industrially and what challenges should be overcome for orally delivered sdAbs to reach the market.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos de Domínio Único
/
Gastroenteropatias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Dinamarca