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Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.
Liu, Pang-Yen; Fukuma, Nobuaki; Hiroi, Yukio; Kunita, Akiko; Tokiwa, Hiroyuki; Ueda, Kazutaka; Kariya, Taro; Numata, Genri; Adachi, Yusuke; Tajima, Miyu; Toyoda, Masayuki; Li, Yuxin; Noma, Kensuke; Harada, Mutsuo; Toko, Haruhiro; Ushiku, Tetsuo; Kanai, Yoshimitsu; Takimoto, Eiki; Liao, James K; Komuro, Issei.
Afiliação
  • Liu PY; Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital Penghu Branch, National Defense Medical Center, Taipei, Taiwan.
  • Fukuma N; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hiroi Y; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kunita A; National Center for Global Health and Medicine, Tokyo, Japan.
  • Tokiwa H; Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, USA.
  • Ueda K; Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • Kariya T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Numata G; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Adachi Y; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tajima M; Department of Anesthesiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • Toyoda M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Li Y; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Noma K; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Harada M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Toko H; Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, USA.
  • Ushiku T; Nihon University School of Medicine, Tokyo, Japan.
  • Kanai Y; Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, USA.
  • Takimoto E; Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
  • Liao JK; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Komuro I; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
JACC Basic Transl Sci ; 8(1): 55-67, 2023 Jan.
Article em En | MEDLINE | ID: mdl-36777173
ABSTRACT
Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan