Enzymatic studies on the mechanism of action of cefoxitin. Correlation between the affinities of cefoxitin to penicillin-binding proteins and its rates of inhibition of the respective penicillin-sensitive reactions in E. coli.
J Antibiot (Tokyo)
; 31(12): 1292-5, 1978 Dec.
Article
em En
| MEDLINE
| ID: mdl-368000
ABSTRACT
The affinities of cefoxitin, a cephamycin antibiotic, to penicillin-binding proteins of Escherichia coli were reexamined using a recently developed method for separating penicillin-binding proteins. The inhibitions by this antibiotic of four measurable penicillin-sensitive enzymatic reactions, the reactions of D-alanine carboxypeptidases IA and IB, cross-bridge formation and concomitant release of D-alanine, were also measured. An approximate correlation was found between the affinities of cefoxitin to the penicillin-binding proteins responsible for these reactions and its rates of inhibition of the respective penicillin-sensitive reactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Proteínas de Bactérias
/
Proteínas de Transporte
/
Cefoxitina
/
Cefalosporinas
/
Escherichia coli
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1978
Tipo de documento:
Article