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Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization.
Zhao, Shuang; He, Yi; Gao, Feiyu; Wei, Yue; Zhang, Jiawei; Chen, Mengxiao; Gao, Yunyun; Zhang, Yuan; Liu, Jun-Yan; Guo, Zufeng; Li, Zhenghua; Nie, Shenyou.
Afiliação
  • Zhao S; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • He Y; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Gao F; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Wei Y; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Zhang J; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Chen M; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Gao Y; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Zhang Y; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Liu JY; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Guo Z; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
  • Li Z; School of Science, Westlake University, Zhejiang 310030, China. ahlzhchem@gmail.com.
  • Nie S; Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China. heyisky@cqmu.edu.cn.
Chem Commun (Camb) ; 59(21): 3099-3102, 2023 Mar 09.
Article em En | MEDLINE | ID: mdl-36804590
Highly efficient synthesis of diverse 2,2-disubstituted 3-methyleneindoline derivatives through a one-pot base-promoted post-Ugi 5-exo-dig "Conia-ene"-type cyclization has been disclosed. The mechanism study indicates that an intramolecular hydrogen bond may play a vital role in this process. The antiproliferative evaluation of cancer cell lines reveals that this protocol provides practical use in the green synthesis of bioactive compound libraries.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China