Risk of retinal vein occlusion following COVID-19 vaccination: a self-controlled case series.
Eye (Lond)
; 37(14): 3000-3003, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-36813998
ABSTRACT
BACKGROUND:
To evaluate the association between COVID-19 vaccination and retinal vein occlusion (RVO).METHODS:
This multicentre self-controlled case series included patients with RVO seen in five tertiary referral centres in Italy. All adults who received at least one dose of the BNT162b2, ChAdOx1 nCoV-19, mRNA-1273 or Ad26.COV2.S vaccine and had a first diagnosis of RVO between January 01, 2021, and December 31, 2021 were included. Incidence rate ratios (IRRs) of RVO were estimated using Poisson regression, comparing rates of events in a 28-day period following each dose of vaccination and in the unexposed control periods.RESULTS:
210 patients were included in the study. No increased risk of RVO was observed after the first dose (1-14 days IRR 0.87, 95% CI 0.41-1.85; 15-28 days IRR 1.01, 95% CI 0.50-2.04; 1-28 days IRR 0.94, 95% CI 0.55-1.58) and second dose of vaccination (1-14 days IRR 1.21, 95% CI 0.62-2.37; 15-28 days IRR 1.08, 95% CI 0.53-2.20; 1-28 days IRR 1.16, 95% CI 0.70-1.90). No association between RVO and vaccination was found in subgroup analyses by type of vaccine, gender and age.CONCLUSIONS:
This self-controlled case series found no evidence of an association between RVO and COVID-19 vaccination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oclusão da Veia Retiniana
/
Vacinas contra COVID-19
/
COVID-19
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Eye (Lond)
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália