Interaction between Changan Granule and its main components in the plasma and CYP450 enzymes.

Liu, Xiaoxuan; Wang, Qiaoxia; Chen, Meng; Tao, Jiayue; Wang, Jing; Liu, Siqi; Hou, Jincai; Li, Dan; Wang, Rufeng

Liu, Xiaoxuan; Wang, Qiaoxia; Chen, Meng; Tao, Jiayue; Wang, Jing; Liu, Siqi; Hou, Jincai; Li, Dan; Wang, Rufeng.

Afiliação

Liu X; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Wang Q; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address: 20200941094@bucm.edu.cn.
Chen M; China National Institute of Standardization, Beijing, 100191, China.
Tao J; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Wang J; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Liu S; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Hou J; Hebei Shineway Pharmaceutical Co., Ltd., Langfang, 065201, China.
Li D; Hebei Shineway Pharmaceutical Co., Ltd., Langfang, 065201, China. Electronic address: ldyeah@yeah.net.
Wang R; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address: wrf@bucm.edu.cn.

J Ethnopharmacol ; 308: 116303, 2023 May 23.

Article em En | MEDLINE | ID: mdl-36841379

Assuntos

Citocromo P-450 CYP1A2; Síndrome do Intestino Irritável; Humanos; Ratos; Animais; Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP2D6/metabolismo; Citocromo P-450 CYP2E1/metabolismo; Citocromo P-450 CYP3A/metabolismo; Cromatografia Líquida; Citocromo P-450 CYP2C9/metabolismo; Citocromo P-450 CYP2C9/farmacologia; Síndrome do Intestino Irritável/metabolismo; Espectrometria de Massas em Tandem; Sistema Enzimático do Citocromo P-450/metabolismo; Microssomos Hepáticos/metabolismo

Palavras-chave

Changan Granule; Cytochrome P450 enzymes; Enzymatic kinetics; HPLC; UPLC-MS/MS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP1A2 / Síndrome do Intestino Irritável Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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