Clinical Validation of the sFlt-1:PlGF Ratio as a Biomarker for Preeclampsia Diagnosis in a High-Risk Obstetrics Unit.
J Appl Lab Med
; 8(3): 457-468, 2023 05 04.
Article
em En
| MEDLINE
| ID: mdl-36869760
ABSTRACT
BACKGROUND:
Preeclampsia is a multisystem disorder defined by new onset of hypertension with proteinuria after 20 weeks gestation. In part due to dysregulation of pro-angiogenic factors (e.g., placental growth factor [PlGF]) and anti-angiogenic factors (e.g., soluble fms-like tyrosine kinase 1 [sFlt-1]), preeclampsia results in decreased placental perfusion. An increased sFlt-1PlGF ratio is associated with increased risk of preeclampsia. In this study, we evaluated sFlt-1PlGF cutoffs and evaluated the clinical performance of sFlt-1PlGF for predicting preeclampsia.METHODS:
sFlt-1PlGF results from 130 pregnant females with clinical suspicion of preeclampsia were used to evaluate the diagnostic accuracy of different sFlt-1PlGF cutoffs and to compare the clinical performance of sFlt-1PlGF to traditional preeclampsia markers (proteinuria and hypertension). Serum sFlt-1 and PlGF were measured using Elecsys immunoassays (Roche Diagnostics) and preeclampsia diagnosis was verified by expert chart review.RESULTS:
A sFlt-1PlGF cutoff of >38 yielded the greatest diagnostic accuracy of 90.8% (95% CI, 85.8%-95.7%). Using a cutoff of >38, sFlt-1PlGF exhibited a greater diagnostic accuracy than traditionally used parameters such as new or worsening proteinuria or hypertension (71.9% and 68.6%, respectively). sFlt-1PlGF >38 exhibited a negative predictive value (NPV) of 96.4% for rule-out of preeclampsia within 7 days, and a positive predictive value (PPV) of 84.8% for predicting preeclampsia within 28 days.CONCLUSIONS:
Our study shows the superior clinical performance of sFlt-1PlGF over hypertension and proteinuria alone to predict preeclampsia at a high-risk obstetrical unit.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Appl Lab Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá