Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes.

De Bortoli, Marzia; Meraviglia, Viviana; Mackova, Katarina; Frommelt, Laura S; König, Eva; Rainer, Johannes; Volani, Chiara; Benzoni, Patrizia; Schlittler, Maja; Cattelan, Giada; Motta, Benedetta M; Volpato, Claudia; Rauhe, Werner; Barbuti, Andrea; Zacchigna, Serena; Pramstaller, Peter P; Rossini, Alessandra

De Bortoli, Marzia; Meraviglia, Viviana; Mackova, Katarina; Frommelt, Laura S; König, Eva; Rainer, Johannes; Volani, Chiara; Benzoni, Patrizia; Schlittler, Maja; Cattelan, Giada; Motta, Benedetta M; Volpato, Claudia; Rauhe, Werner; Barbuti, Andrea; Zacchigna, Serena; Pramstaller, Peter P; Rossini, Alessandra.

Afiliação

De Bortoli M; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Meraviglia V; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Mackova K; Department of Anatomy and Embryology, Leiden University Medical Center, 2316 Leiden, the Netherlands.
Frommelt LS; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
König E; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Rainer J; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Volani C; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Benzoni P; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Schlittler M; Universita` degli Studi di Milano, The Cell Physiology MiLab, Department of Biosciences, Milano, Italy.
Cattelan G; Universita` degli Studi di Milano, The Cell Physiology MiLab, Department of Biosciences, Milano, Italy.
Motta BM; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Volpato C; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Rauhe W; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Barbuti A; Institute for Biomedicine (Affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy.
Zacchigna S; San Maurizio Hospital, Department of Cardiology, Bolzano, Italy.
Pramstaller PP; Universita` degli Studi di Milano, The Cell Physiology MiLab, Department of Biosciences, Milano, Italy.
Rossini A; International Centre for Genetic Engineering and Biotechnology (ICGEB), Cardiovascular Biology Laboratory, Trieste, Italy.

Comput Struct Biotechnol J ; 21: 1759-1773, 2023.

Article em En | MEDLINE | ID: mdl-36915380

Palavras-chave

ABC, active ß-catenin; ACM, arrhythmogenic cardiomyopathy; ASY, asymptomatic; Arrhythmogenic cardiomyopathy; BBB, bundle-branch block; CMs, cardiomyocytes; CTR, control; Cx43, connexin-43; DEGs, differentially expressed genes; GATK, Genome Analysis Toolkit; Human induced pluripotent stem cell derived cardiomyocytes; ICD, implantable cardioverter-defibrillator; ID, intercalated disk; Incomplete penetrance; LBB, left bundle-branch block; MRI, magnetic resonance imagingmut, mutated; NSVT, non-sustained ventricular tachycardia; RV, right ventricle; hiPSC, human induced pluripotent stem cell; wt, wild type

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Comput Struct Biotechnol J Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google