Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.

Keating, Sean S; Bademosi, Adekunle T; San Gil, Rebecca; Walker, Adam K

Keating, Sean S; Bademosi, Adekunle T; San Gil, Rebecca; Walker, Adam K.

Afiliação

Keating SS; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia.
Bademosi AT; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia.
San Gil R; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia. r.sangil@uq.edu.au.
Walker AK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia, QLD, 4072, Australia. adam.walker@uq.edu.au.

Cell Mol Life Sci ; 80(4): 95, 2023 Mar 17.

Article em En | MEDLINE | ID: mdl-36930291

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Humanos; Esclerose Lateral Amiotrófica/metabolismo; Núcleo Celular/metabolismo; Citoplasma/metabolismo; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Demência Frontotemporal/genética; Demência Frontotemporal/metabolismo

Palavras-chave

Acetylated TDP-43; Endogenous gene tagging; LLPS; Motor neuron disease; TDP-43 loss of function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália

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