Your browser doesn't support javascript.
loading
Six-month effective treatment of corneal graft rejection.
Meng, Tuo; Zheng, Jinhua; Chen, Min; Zhao, Yang; Sudarjat, Hadi; M R, Aji Alex; Kulkarni, Vineet; Oh, Yumin; Xia, Shiyu; Ding, Zheng; Han, Hyounkoo; Anders, Nicole; Rudek, Michelle A; Chow, Woon; Stark, Walter; Ensign, Laura M; Hanes, Justin; Xu, Qingguo.
Afiliação
  • Meng T; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Zheng J; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Chen M; Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
  • Zhao Y; Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, Shandong 266073, China.
  • Sudarjat H; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • M R AA; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Kulkarni V; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Oh Y; Department of Ophthalmology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • Xia S; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Ding Z; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Han H; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Anders N; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Rudek MA; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Chow W; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Stark W; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Ensign LM; Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.
  • Hanes J; Department of Medicine, The Johns Hopkins University, Baltimore, MD 21231, USA.
  • Xu Q; Department of Medicine, The Johns Hopkins University, Baltimore, MD 21231, USA.
Sci Adv ; 9(12): eadf4608, 2023 03 22.
Article em En | MEDLINE | ID: mdl-36947612
ABSTRACT
Topical corticosteroid eye drop is the mainstay for preventing and treating corneal graft rejection. While the frequent topical corticosteroid use is associated with risk of intraocular pressure (IOP) elevation and poor patient compliance that leads to graft failure and the requirement for a repeated, high-risk corneal transplantation. Here, we developed dexamethasone sodium phosphate (DSP)-loaded dicarboxyl-terminated poly(lactic acid) nanoparticle (PLA DSP-NP) formulations with relatively high drug loading (8 to 10 weight %) and 6 months of sustained intraocular DSP delivery in rats with a single dosing. PLA DSP-NP successfully reversed early signs of corneal rejection, leading to rat corneal graft survival for at least 6 months. Efficacious PLA DSP-NP doses did not affect IOP and showed no signs of ocular toxicity in rats for up to 6 months. Subconjunctival injection of DSP-NP is a promising approach for safely preventing and treating corneal graft rejection with the potential for improved patient adherence.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças da Córnea / Rejeição de Enxerto Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças da Córnea / Rejeição de Enxerto Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos