Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion.

Arifin, Maria I; Kaczmarczyk, Lech; Zeng, Doris; Hannaoui, Samia; Lee, Chi; Chang, Sheng Chun; Mitchell, Gordon; McKenzie, Debbie; Beekes, Michael; Jackson, Walker; Gilch, Sabine

Arifin, Maria I; Kaczmarczyk, Lech; Zeng, Doris; Hannaoui, Samia; Lee, Chi; Chang, Sheng Chun; Mitchell, Gordon; McKenzie, Debbie; Beekes, Michael; Jackson, Walker; Gilch, Sabine.

Afiliação

Arifin MI; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.
Kaczmarczyk L; Department of Clinical and Experimental Medicine, Wallenberg Center for Molecular Medicine, Linköping University, Linköping 581 83, Sweden.
Zeng D; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.
Hannaoui S; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.
Lee C; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.
Chang SC; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.
Mitchell G; National and World Organisation for Animal Health Reference Laboratory for Scrapie and Chronic Wasting Disease, Canadian Food Inspection Agency, Ontario K1A 0Y9, Canada.
McKenzie D; Department of Biological Sciences and Centre for Prions and Protein Folding Diseases, University of Alberta, Alberta T6G 2M8, Canada.
Beekes M; Prion and Prionoid Research Unit, Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin 13353, Germany.
Jackson W; Department of Clinical and Experimental Medicine, Wallenberg Center for Molecular Medicine, Linköping University, Linköping 581 83, Sweden.
Gilch S; Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Alberta T2N 4Z6, Canada.

Proc Natl Acad Sci U S A ; 120(15): e2221060120, 2023 04 11.

Article em En | MEDLINE | ID: mdl-37014866

Assuntos

Cervos; Doenças Priônicas; Príons; Rena; Doença de Emaciação Crônica; Camundongos; Animais; Príons/metabolismo; Proteínas Priônicas/genética; Cervos/genética; Doença de Emaciação Crônica/genética; Camundongos Transgênicos; Doenças Priônicas/genética

Palavras-chave

chronic wasting disease; gene-targeted mouse model; pmca; prion; prion protein polymorphism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Cervos / Rena / Doenças Priônicas / Doença de Emaciação Crônica Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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