A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-&#954;B signaling activation and gut microbiota modification in H22 tumor-bearing mice.

Zhao, Jiahui; He, Rongjun; Zhong, Hao; Liu, Shizhu; Liu, Xiaofeng; Hussain, Muhammad; Sun, Peilong

A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice.

Zhao, Jiahui; He, Rongjun; Zhong, Hao; Liu, Shizhu; Liu, Xiaofeng; Hussain, Muhammad; Sun, Peilong.

Afiliação

Zhao J; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
He R; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Bioactives and Functional Foods Research Center, China National Light Industry, Hangzhou 310014, China; Zhejiang Fangge Pharmaceutical Co., Ltd., Qingyuan 323800, China. Electronic address: hrjun@zjut.
Zhong H; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Bioactives and Functional Foods Research Center, China National Light Industry, Hangzhou 310014, China.
Liu S; Zhejiang Fangge Pharmaceutical Co., Ltd., Qingyuan 323800, China.
Liu X; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Bioactives and Functional Foods Research Center, China National Light Industry, Hangzhou 310014, China.
Hussain M; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Sun P; College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Key Laboratory of Food Macromolecular Resources Processing Technology Research, China National Light Industry, Hangzhou 310014, China; Zhejiang Fangge Pharmaceutical Co., Ltd., Qingyuan 323800, China.

Int J Biol Macromol ; 239: 124291, 2023 Jun 01.

Article em En | MEDLINE | ID: mdl-37028620

Assuntos

Carcinoma; Microbioma Gastrointestinal; Grifola; Animais; Camundongos; NF-kappa B/metabolismo; Grifola/química; Receptor 4 Toll-Like; Polissacarídeos/farmacologia; Polissacarídeos/química; Água/química

Palavras-chave

Anti-tumor; Grifola frondosa; Gut microbiota; Polysaccharide-protein complex; TLR4-NF-κB pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Grifola / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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