Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration.

Hao, Han; Zhang, Yao; Hu, Xiaoxiao; Guo, Wei; Yang, Caiqin; Wang, Jing

Hao, Han; Zhang, Yao; Hu, Xiaoxiao; Guo, Wei; Yang, Caiqin; Wang, Jing.

Afiliação

Hao H; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Zhang Y; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Hu X; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Guo W; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Yang C; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Wang J; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China. Electronic address: jingwang@home.ipe.ac.cn.

Eur J Pharm Biopharm ; 187: 12-23, 2023 Jun.

Article em En | MEDLINE | ID: mdl-37031731

Assuntos

Antineoplásicos; Neoplasias; Camundongos; Animais; Fluoruracila/farmacologia; Fluoruracila/química; Espectroscopia de Infravermelho com Transformada de Fourier/métodos; Injeções Intraperitoneais; Pós; Antineoplásicos/farmacologia; Difração de Raios X; Solubilidade; Varredura Diferencial de Calorimetria

Palavras-chave

5-Fluorouracil; Autophagy flux; Cocrystal; Gallic acid; Synergism activity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Animals Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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