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Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men.
Ren, Jingchao; Jin, Huidong; Zhang, Chen; Liu, Song; Han, Yufen; Xi, Jinyan; Cao, Jinhu; Lin, Fenglong; Zhang, Pingyang; Zhang, Fengquan; Zhang, Guang-Hui; Yang, Huijun; Huang, Hefeng; Cao, Jia.
Afiliação
  • Ren J; School of Public Health and Management, Chongqing Medical University, Chongqing, 400038, China; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Jin H; Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Zhang C; Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200032, China; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), Shanghai, China.
  • Liu S; Reproductive Medicine Centre, Maternal and Child Health Care Hospital of Shandong Province, Jinan, 250014, China.
  • Han Y; Puyang Maternity and Child Care Centers, 59 South Section of Kaizhou Road, Puyang, 457000, China.
  • Xi J; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Cao J; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Lin F; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Zhang P; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Zhang F; Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
  • Zhang GH; Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Yang H; Reproductive Medicine Centre, Maternal and Child Health Care Hospital of Shandong Province, Jinan, 250014, China. Electronic address: lwyhj@163.com.
  • Huang H; Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200032, China; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), Shanghai, China. Electronic address: huanghefg@hotmail.com.
  • Cao J; Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address: caojia1962@126.com.
Environ Res ; 229: 115888, 2023 07 15.
Article em En | MEDLINE | ID: mdl-37054833
BACKGROUND: The effects of metal exposure on semen quality and the role of oxidative damage in this process remain unclear. METHODS: We recruited 825 Chinese male volunteers, and 12 seminal metals (Mn, Cu, Zn, Se, Ni, Cd, Pb, Co, Ag, Ba, Tl, and Fe), the total antioxidant capacity (TAC), and reduced glutathione were measured. Semen parameters and GSTM1/GSTT1-null genotypes were also detected. Bayesian kernel machine regression (BKMR) was applied to evaluate the effect of the mixed exposure to metals on semen parameters. The mediation of TAC and moderation of GSTM1/GSTT1 deletion were analyzed. RESULTS: Most seminal metal concentrations were correlated with each other. The BKMR models revealed a negative association between the semen volume and metal mixture, with Cd (cPIP = 0.60) and Mn (cPIP = 0.10) as the major contributors. Compared to fixing all scaled metals at their median value (50th percentiles), fixing the scaled metals at their 75th percentiles decreased the TAC by 2.17 units (95%CI: -2.60, -1.75). Mediation analysis indicated that Mn decreased the semen volume, with 27.82% of this association mediated by TAC. Both the BKMR and multi-linear models showed that seminal Ni was negatively correlated with sperm concentration, total sperm count, and progressive motility, which was modified by GSTM1/GSTT1. Furthermore, Ni and the total sperm count showed a negative association in GSTT1 and GSTM1 null males (ß[95%CI]: 0.328 [-0.521, -0.136]) but not in males with GSTT1 and/or GSTM1. Although Fe and the sperm concentration and total sperm count were positively correlated, they showed inverse "U" shapes in univariate analysis. CONCLUSION: Exposure to the 12 metals was negatively associated with semen volume, with Cd and Mn as the major contributors. TAC may mediate this process. GSTT1 and GSTM1 can modify the reduction in the total sperm count caused by seminal Ni exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise do Sêmen / Glutationa Transferase / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Environ Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise do Sêmen / Glutationa Transferase / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Environ Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China