Effect of Non-Specific Porins from the Outer Membrane of Yersinia pseudotuberculosis on Mice Brain Cortex Tissues.
Biochemistry (Mosc)
; 88(1): 142-151, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-37068878
ABSTRACT
It was found that a single-dose immunization of mice with Yersinia pseudotuberculosis porins OmpF and OmpC causes development of pathological changes in the deep layers of cerebral cortex characterized by dystrophic changes in the cells against the background of the increasing titer of specific antibodies. At the same time, the increased level of caspase-3 expression is observed in the neurons, which indicates induction of proapoptotic signaling pathways. The obtained results indicate potential ability of nonspecific pore-forming proteins of the outer membrane of Gram-negative bacteria to initiate development of degenerative changes in brain cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Yersinia pseudotuberculosis
Limite:
Animals
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Federação Russa