Using pentamidine to treat cutaneous leishmaniasis in children: a 10-year study in French Guiana.
Clin Exp Dermatol
; 48(8): 913-915, 2023 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-37075241
ABSTRACT
There are little data on pentamidine as a treatment for paediatric cutaneous leishmaniasis (CL). The objective of this study was to describe the effectiveness and safety of pentamidine over a 10-year period. Every child seen in French Guiana between 2010 and 2020 with proven CL and treated with pentamidine was included. In total, 55 children met the inclusion criteria - 23 girls and 32 boys. There were 38 patients (38/55, 69%) with a > 50% improvement at 1â
month after pentamidine treatment and a complete cure at 3â
months; 16 children had a < 50% improvement at 1â
month and were given a second dose. Of these 16, 8 showed a complete cure at 3â
months, 5 were lost to follow-up and 3 showed therapeutic failure at 3â
months. The overall cure rate was 84% (46/55) after one or two doses. In terms of the safety of pentamidine, no severe adverse events (grade ≥ 3) were reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmaniose Cutânea
/
Antiprotozoários
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Caribe ingles
/
Guyana
/
Guyana francesa
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2023
Tipo de documento:
Article