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NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores.
Gola, Lukas; Bierhansl, Laura; Csatári, Júlia; Schroeter, Christina B; Korn, Lisanne; Narayanan, Venu; Cerina, Manuela; Abdolahi, Sara; Speicher, Anna; Hermann, Alexander M; König, Simone; Dinkova-Kostova, Albena T; Shekh-Ahmad, Tawfeeq; Meuth, Sven G; Wiendl, Heinz; Gorji, Ali; Pawlowski, Matthias; Kovac, Stjepana.
Afiliação
  • Gola L; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Bierhansl L; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Csatári J; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Schroeter CB; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Korn L; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Narayanan V; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Cerina M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Abdolahi S; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
  • Speicher A; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Hermann AM; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • König S; Core Unit Proteomics, Interdisciplinary Center for Clinical Research, Medical Faculty, University of Münster, 48149, Münster, Germany.
  • Dinkova-Kostova AT; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.
  • Shekh-Ahmad T; Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel.
  • Meuth SG; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
  • Gorji A; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
  • Pawlowski M; Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, 48149, Münster, Germany.
  • Kovac S; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
Cell Mol Life Sci ; 80(5): 127, 2023 Apr 21.
Article em En | MEDLINE | ID: mdl-37081190
Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to hyperexcitation and increased reactive oxygen species (ROS) levels are observed in various neurological diseases. NOX4 is an NADPH oxidase known to produce ROS and might have a regulating function during oxidative stress. We, therefore, aimed to determine the role of NOX4 on neuronal firing, hyperexcitability, and hyperexcitability-induced changes in neural network function. Using a multidimensional approach of an in vivo model of hyperexcitability, proteomic analysis, and cellular function analysis of ROS, mitochondrial integrity, and calcium levels, we demonstrate that NOX4 is neuroprotective by regulating ROS and calcium homeostasis and thereby preventing hyperexcitability and consequently neuronal death. These results implicate NOX4 as a potential redox regulator that is beneficial in hyperexcitability and thereby might have an important role in neurodegeneration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Proteômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Proteômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha