The host antiviral protein SAMHD1 suppresses NF-&#954;B activation by interacting with the IKK complex during inflammatory responses and viral infection.

Yang, Hua; Espada, Constanza E; Phillips, Stacia; Martinez, Nicholas; Kenney, Adam D; Yount, Jacob S; Xiong, Yong; Wu, Li

The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection.

Yang, Hua; Espada, Constanza E; Phillips, Stacia; Martinez, Nicholas; Kenney, Adam D; Yount, Jacob S; Xiong, Yong; Wu, Li.

Afiliação

Yang H; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Espada CE; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Phillips S; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Martinez N; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.
Kenney AD; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Yount JS; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.
Wu L; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. Electronic address: li-wu@uiowa.edu.

J Biol Chem ; 299(6): 104750, 2023 06.

Article em En | MEDLINE | ID: mdl-37100289

Assuntos

Quinase I-kappa B; Proteína 1 com Domínio SAM e Domínio HD; Viroses; Humanos; Quinase I-kappa B/genética; Quinase I-kappa B/metabolismo; NF-kappa B/genética; NF-kappa B/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; Fosforilação; Proteína 1 com Domínio SAM e Domínio HD/genética; Proteína 1 com Domínio SAM e Domínio HD/metabolismo; Viroses/imunologia; Viroses/metabolismo; Linhagem Celular

Palavras-chave

IKKα; IKKß; IKKÎ³; NF-κB; SAMHD1; TAK1; THP-1 cells; immunoprecipitation; phosphorylation; viral infection

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viroses / Quinase I-kappa B / Proteína 1 com Domínio SAM e Domínio HD Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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