Duration of type 2 diabetes and liver-related events in nonalcoholic fatty liver disease: A landmark analysis.
Hepatology
; 78(6): 1816-1827, 2023 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-37119179
ABSTRACT
BACKGROUND AND AIMS:
We aimed to determine the impact of the duration of type 2 diabetes (T2D) on the risk of liver-related events and all-cause mortality in patients with NAFLD. APPROACH ANDRESULTS:
We conducted a territory-wide cohort study of adult patients with NAFLD diagnosed between January 1, 2000, and July 31, 2021, in Hong Kong. T2D was defined by the use of any antidiabetic agents, laboratory tests, and/or diagnosis codes. The primary endpoint was liver-related events, defined as a composite endpoint of HCC and cirrhotic complications. To conduct a more granular assessment of the duration of T2D, we employed landmark analysis in four different ages of interest (biological age of 40, 50, 60, and 70 years). By multivariable analysis with adjustment of non-liver-related deaths, compared with patients without diabetes at age 60 (incidence rate of liver-related events 0.70 per 1,000 person-years), the adjusted subdistribution HR (SHR) of liver-related events was 2.51 (95% CI 1.32-4.77; incidence rate 2.26 per 1,000 person-years) in patients with T2D duration < 5 years, 3.16 (95% CI 1.59-6.31; incidence rate 2.54 per 1,000 person-years) in those with T2D duration of 6-10 years, and 6.20 (95% CI 2.62-14.65; incidence rate 4.17 per 1000 person-years) in those with T2D duration more than 10 years. A similar association between the duration of T2D and all-cause mortality was also observed.CONCLUSIONS:
Longer duration of T2D is significantly associated with a higher risk of liver-related events and all-cause mortality in patients with NAFLD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
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Diabetes Mellitus Tipo 2
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Hepatopatia Gordurosa não Alcoólica
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Neoplasias Hepáticas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Middle aged
Idioma:
En
Revista:
Hepatology
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China