Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small-molecule antibiotics.

van Wieren, Arie; Durrant, Jacob D; Majumdar, Sudipta

van Wieren, Arie; Durrant, Jacob D; Majumdar, Sudipta.

Afiliação

van Wieren A; Madia Department of Chemistry, Biochemistry, Physics and Engineering, Indiana University of Pennsylvania, Indiana, Pennsylvania, USA.
Durrant JD; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Majumdar S; Madia Department of Chemistry, Biochemistry, Physics and Engineering, Indiana University of Pennsylvania, Indiana, Pennsylvania, USA.

Drug Dev Res ; 84(5): 999-1007, 2023 08.

Article em En | MEDLINE | ID: mdl-37129190

Assuntos

Alanina Racemase; Mycobacterium tuberculosis; Humanos; Antibacterianos/farmacologia; Alanina Racemase/genética; Alanina Racemase/química; Alanina Racemase/metabolismo; Domínio Catalítico; Mycobacterium tuberculosis/genética; Farmacorresistência Bacteriana

Palavras-chave

alanine racemase; antibiotic; computer-aided drug design; drug discovery; enzyme kinetics; protein structure-function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alanina Racemase / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Drug Dev Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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