Astragaloside IV attenuates high glucose-induced NF-&#954;B-mediated inflammation through activation of PI3K/AKT-ERK-dependent Nrf2/ARE signaling pathway in glomerular mesangial cells.

Su, Xue; Guo, Hengjiang; Zhou, Yuying; Cao, Aili; Shen, Qian; Zhu, Bingbing; Yao, Xingmei; Wang, Yunman; Wang, Hao; Wang, Li

Astragaloside IV attenuates high glucose-induced NF-κB-mediated inflammation through activation of PI3K/AKT-ERK-dependent Nrf2/ARE signaling pathway in glomerular mesangial cells.

Su, Xue; Guo, Hengjiang; Zhou, Yuying; Cao, Aili; Shen, Qian; Zhu, Bingbing; Yao, Xingmei; Wang, Yunman; Wang, Hao; Wang, Li.

Afiliação

Su X; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Guo H; Department of Anesthesiology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhou Y; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Cao A; Department of Nephrology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shen Q; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhu B; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yao X; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang Y; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang H; Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang L; Shanghai Putuo Central School of Clinical Medicine, Anhui Medical University, Hefei, China.

Phytother Res ; 37(9): 4133-4148, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37189016

Assuntos

NF-kappa B; Proteínas Proto-Oncogênicas c-akt; Humanos; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Antioxidantes/farmacologia; Células Mesangiais/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Fosfatidilinositol 3-Quinase/metabolismo; Estresse Oxidativo; Citocinas/metabolismo; Glucose/metabolismo; Inflamação/metabolismo

Palavras-chave

Astragaloside IV; diabetic kidney disease; glomerular mesangial cells; inflammation; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Proteínas Proto-Oncogênicas c-akt Limite: Humans Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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