Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain.

Xu, Ling-Jun; Wang, Jing; Li, Yu-Dan; Shen, Kai-Feng; He, Xing-Hui; Wu, Wei; Liu, Cui-Cui

Xu, Ling-Jun; Wang, Jing; Li, Yu-Dan; Shen, Kai-Feng; He, Xing-Hui; Wu, Wei; Liu, Cui-Cui.

Afiliação

Xu LJ; Department of Pain Management, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Wang J; Department of Pain Management, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China; Zhongshan School of Medicine, Yat-sen University, Guangzhou, China.
Li YD; Department of Ultrasound, The Third People's Hospital of Shenzhen, Shenzhen, China.
Shen KF; Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
He XH; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Wu W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Liu CC; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Pain Physician ; 26(3): E213-E222, 2023 05.

Article em En | MEDLINE | ID: mdl-37192244

Assuntos

Neuralgia; Sirtuína 1; Ratos; Animais; Oxaliplatina/efeitos adversos; Oxaliplatina/metabolismo; Regulação para Cima; Sirtuína 1/genética; Sirtuína 1/metabolismo; Sirtuína 1/farmacologia; Hiperalgesia/induzido quimicamente; Hiperalgesia/tratamento farmacológico; Hiperalgesia/genética; Ratos Sprague-Dawley; Histonas/genética; Histonas/metabolismo; Histonas/farmacologia; Epigênese Genética; Resveratrol/efeitos adversos; Resveratrol/metabolismo; Neuralgia/metabolismo; Gânglios Espinais/metabolismo; RNA Interferente Pequeno/metabolismo

Palavras-chave

NAV1.7 voltage-gated sodium channel; dorsal root ganglion; neuropathic pain; oxaliplatin; SIRT1

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sirtuína 1 / Neuralgia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pain Physician Assunto da revista: PSICOFISIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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