Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing.

Garana, Belinda B; Joly, James H; Delfarah, Alireza; Hong, Hyunjun; Graham, Nicholas A

Garana, Belinda B; Joly, James H; Delfarah, Alireza; Hong, Hyunjun; Graham, Nicholas A.

Afiliação

Garana BB; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 3710 McClintock Ave., RTH 509, Los Angeles, CA, 90089, USA.
Joly JH; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 3710 McClintock Ave., RTH 509, Los Angeles, CA, 90089, USA.
Delfarah A; Nautilus Biotechnology, San Carlos, CA, USA.
Hong H; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 3710 McClintock Ave., RTH 509, Los Angeles, CA, 90089, USA.
Graham NA; Calico Life Sciences, South San Francisco, CA, USA.

BMC Bioinformatics ; 24(1): 215, 2023 May 24.

Article em En | MEDLINE | ID: mdl-37226094

Assuntos

Reposicionamento de Medicamentos; Senoterapia; Humanos; Linhagem Celular; Biologia Computacional

Palavras-chave

Drug repurposing; Enrichment analysis; Gene expression analysis; Mechanism of action; Precision medicine; Proteomic analysis; Senescence; Senolytic; Targeted therapeutics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reposicionamento de Medicamentos / Senoterapia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Bioinformatics Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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