A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.

Sobh, Eman A; Dahab, Mohammed A; Elkaeed, Eslam B; Alsfouk, Bshra A; Ibrahim, Ibrahim M; Metwaly, Ahmed M; Eissa, Ibrahim H

Sobh, Eman A; Dahab, Mohammed A; Elkaeed, Eslam B; Alsfouk, Bshra A; Ibrahim, Ibrahim M; Metwaly, Ahmed M; Eissa, Ibrahim H.

Afiliação

Sobh EA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Shibin-Elkom, Egypt.
Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Alsfouk BA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt.
Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Eissa IH; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt.

Drug Dev Res ; 84(6): 1247-1265, 2023 09.

Article em En | MEDLINE | ID: mdl-37232504

Assuntos

Antineoplásicos; Receptor 2 de Fatores de Crescimento do Endotélio Vascular; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Simulação de Acoplamento Molecular; Fator A de Crescimento do Endotélio Vascular; Antineoplásicos/farmacologia; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Proliferação de Células; Descoberta de Drogas; Pirimidinas/farmacologia; Pirimidinas/química

Palavras-chave

CADD; MD simulations; VEGFR-2 inhibitors; apoptosis; docking; thieno[2,3-d]pyrimidine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Dev Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito

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