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Cobalt-Catalyzed Chemoselective Reduction of N-Heteroaryl Ketones with N,N-Dimethylformamide as a Hydride Source.
Yu, Rurong; Hao, Feiyue; Zhang, Xinyu; Fang, Zhongbing; Jin, Zhengneng; Liu, Guyue; Dai, Guoliang; Wu, Jiashou.
Afiliação
  • Yu R; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Hao F; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Zhang X; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Fang Z; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Jin Z; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Liu G; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
  • Dai G; School of Chemical Biology and Materials Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
  • Wu J; School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, China.
J Org Chem ; 88(13): 8279-8285, 2023 Jul 07.
Article em En | MEDLINE | ID: mdl-37257025
ABSTRACT
A method for chemoselective reduction of 2-pyridyl ketones and related N-heteroaryl compounds catalyzed by cobalt stearate using DMF as a hydride source is developed. The ketone substrate is activated by chelation with cobalt, which makes the present method highly chemoselective. A possible reaction mechanism is proposed on the basis of control experiments.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dimetilformamida / Cetonas Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dimetilformamida / Cetonas Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China