Linking Body Composition and Nutritional Status with CAR T-cell Efficacy.
Cancer Immunol Res
; 11(6): 704, 2023 06 02.
Article
em En
| MEDLINE
| ID: mdl-37264818
ABSTRACT
Obesity and its attendant pathophysiological alterations have long been implicated in promoting cancer development and in the modulation of antitumor immunologic responses, but little is known about their impact on outcomes after cellular immunotherapy. In this issue, Rejeski and colleagues report that intrinsic host factors including body composition and nutritional status may predict response after chimeric antigen receptor T-cell therapy in patients with relapsed lymphomas. These data highlight the clinical relevance of these factors on treatment outcomes and will hopefully motivate interventional studies of prehabilitation and nutritional optimization in these patients. See related article by Rejeski et al., p. 707 (1).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
/
Sarcopenia
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Immunol Res
Ano de publicação:
2023
Tipo de documento:
Article