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Protective Effect of Ursodeoxycholic Acid on Liver Function in Pediatric Patients with Seizure Treated with Phenobarbital.
Keikhaie, Khadije Rezaie; Mohammadi, Mohammad Hasan; Saravani, Khadijeh; Kahkhaie, Leli Rezaie; Mir, Fatemeh.
Afiliação
  • Keikhaie KR; Department of Obstetrics and Gynecology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Mohammadi MH; Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.
  • Saravani K; Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.
  • Kahkhaie LR; Department of Community Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Mir F; Department of Internal Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Maedica (Bucur) ; 18(1): 42-49, 2023 Mar.
Article em En | MEDLINE | ID: mdl-37266459
BackgroundEpilepsy is a common and devastating neurological disease. Its treatment, especially when using phenobarbital, causes liver complications, and it is therefore essential to identify a way to reduce liver complications. This study aimed to investigate the protective effect of ursodeoxycholic acid on liver function in pediatric patients with seizure treated with phenobarbital. Materials and methods:Materials and methods: The present study was conducted on 80 patients (40 in the placebo group and 40 in the ursodeoxycholic acid group). To assess the effect of intervention, liver enzyme levels after five weeks of treatment were recorded. Independent t-test and ANOVA repeated measures were used to compare the means. Conclusions:The study results showed that the administration of ursodeoxycholic acid had a relative effect in improving liver function in patients with liver injury caused by phenobarbital.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Maedica (Bucur) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Maedica (Bucur) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã