Alterations in lipid and hormonal titers in patients with acne and their relationship with severity: A case-control study.

ABSTRACT

Background and Aims: Acne is a frequently diagnosed skin condition that causes pilosebaceous apparatus clogs and/or inflammatory responses in the majority of teenagers. It is a multifactorial disease that can develop due to various factors. We aimed to evaluate lipid profiles and hormonal levels in patients with acne and correlate them to acne severity. We also aim to explore the alteration of lipid profiles and hormonal levels and their effect on the occurrence of acne. Methods: A case-control study was performed on 100 individuals with acne vulgaris and 100 healthy controls. The biochemical analysis included; lipid profiles such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), and hormonal levels such as estradiol (E), total testosterone (TT), and free testosterone (FT) were measured for both patients and controls. Results: Comparison between patients with acne and controls disclosed that; TC, TG, LDL-C, and HDL-C levels were significantly higher in patients, especially when compared to controls (p ≤ 0.05); also, the same results were found in hormonal levels results (p ≤ 0.05). Conclusion: These altered lipid profiles and androgen levels should be considered in the pathophysiology of acne and taken into consideration when treating patients with acne.