[Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway].

Xu, Yan; Liu, Dong-Guang; Ning, Ting-Bo; Zhu, Jian-Guo; Yao, Ru; Meng, Xue; Yao, Jing-Chun; Zhao, Wen-Xue

Xu, Yan; Liu, Dong-Guang; Ning, Ting-Bo; Zhu, Jian-Guo; Yao, Ru; Meng, Xue; Yao, Jing-Chun; Zhao, Wen-Xue.

Afiliação

Xu Y; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Liu DG; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Ning TB; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Zhu JG; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Yao R; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Meng X; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Yao JC; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.
Zhao WX; New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China.

Zhongguo Zhong Yao Za Zhi ; 48(8): 2184-2192, 2023 Apr.

Article em Zh | MEDLINE | ID: mdl-37282906

Assuntos

Fator Neurotrófico Derivado do Encéfalo; Fator de Crescimento Neural; Ratos; Masculino; Animais; Proteína X Associada a bcl-2/metabolismo; Caspase 3/metabolismo; Fator de Crescimento Neural/metabolismo; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Transdução de Sinais; Fator de Necrose Tumoral alfa/metabolismo; Serotonina/metabolismo; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Ratos Sprague-Dawley; Antidepressivos/farmacologia; Hipocampo/metabolismo; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Açúcares/farmacologia; Depressão/tratamento farmacológico; Depressão/genética; Estresse Psicológico/tratamento farmacológico; Estresse Psicológico/metabolismo

Palavras-chave

BDNF/TrkB/CREB pathway; Nrf2/HO-1 pathway; Shenling Kaixin Granules; caspase-3 pathway; chronic unpredictable mild stress(CUMS); depression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Fator de Crescimento Neural Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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