Your browser doesn't support javascript.
loading
The protective effect of 7-hydroxycoumarin against cisplatin-induced liver injury is mediated via attenuation of oxidative stress and inflammation and upregulation of Nrf2/HO-1 pathway.
Sami, Demiana H; Soliman, Ayman S; Khowailed, Akef A; Alruhaimi, Reem S; Hassanein, Emad H M; Kamel, Emadeldin M; Mahmoud, Ayman M.
Afiliação
  • Sami DH; Physiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, 62514, Egypt.
  • Soliman AS; Physiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, 62514, Egypt.
  • Khowailed AA; Physiology Department, Faculty of Medicine, Cairo University, Giza, 12613, Egypt.
  • Alruhaimi RS; Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia.
  • Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University-Assiut Branch, Assiut, 71524, Egypt.
  • Kamel EM; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
  • Mahmoud AM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. ayman.mahmoud@science.bsu.edu.eg.
Environ Sci Pollut Res Int ; 30(33): 80181-80191, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37291353
Cisplatin (CIS) is an effective chemotherapy against different solid cancers. However, the adverse effects, including hepatotoxicity, limit its clinical use. 7-hydroxycoumarin (7-HC) possesses antioxidant and hepatoprotective activities, but its protective effect against CIS hepatotoxicity has not been investigated. This study evaluated the effect of 7-HC on liver injury, oxidative stress (OS), and inflammation provoked by CIS. Rats received 7-HC (25, 50, and 100 mg/kg) orally for 2 weeks followed by intraperitoneal injection of CIS (7 mg/kg) at day 15. CIS increased serum transaminases, alkaline phosphatase (ALP), and bilirubin and provoked tissue injury accompanied by elevated reactive oxygen species (ROS), malondialdehyde (MDA), and nitric oxide (NO). Liver nuclear factor (NF)-κB p65, inducible NO synthase (iNOS), pro-inflammatory cytokines, Bax, and caspase-3 were upregulated, and antioxidant defenses and Bcl-2 were decreased in CIS-treated rats, while 7-HC prevented liver injury and ameliorated OS, inflammatory and apoptosis markers. In addition, 7-HC enhanced nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase (HO)-1 in CIS-administered rats and in silico studies revealed its binding affinity toward HO-1. In conclusion, 7-HC protected against CIS hepatotoxicity by mitigating OS and inflammatory response and modulating Nrf2/HO-1 pathway.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Hepática Crônica Induzida por Substâncias e Drogas / Antioxidantes Limite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Hepática Crônica Induzida por Substâncias e Drogas / Antioxidantes Limite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito