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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.
Lu, Tzu-Chiao; Brbic, Maria; Park, Ye-Jin; Jackson, Tyler; Chen, Jiaye; Kolluru, Sai Saroja; Qi, Yanyan; Katheder, Nadja Sandra; Cai, Xiaoyu Tracy; Lee, Seungjae; Chen, Yen-Chung; Auld, Niccole; Liang, Chung-Yi; Ding, Sophia H; Welsch, Doug; D'Souza, Samuel; Pisco, Angela Oliveira; Jones, Robert C; Leskovec, Jure; Lai, Eric C; Bellen, Hugo J; Luo, Liqun; Jasper, Heinrich; Quake, Stephen R; Li, Hongjie.
Afiliação
  • Lu TC; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Brbic M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Park YJ; School of Computer and Communication Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.
  • Jackson T; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Chen J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Kolluru SS; Program in Development, Disease Models and Therapeutics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Qi Y; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
  • Katheder NS; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Cai XT; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Lee S; Program in Cancer Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Chen YC; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Auld N; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Liang CY; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA.
  • Ding SH; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Welsch D; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
  • D'Souza S; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
  • Pisco AO; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Jones RC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Leskovec J; Regenerative Medicine, Genentech, Inc., South San Francisco, CA 94080, USA.
  • Lai EC; Regenerative Medicine, Genentech, Inc., South San Francisco, CA 94080, USA.
  • Bellen HJ; Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
  • Luo L; Department of Biology, New York University, New York, NY 10013, USA.
  • Jasper H; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Quake SR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Li H; Program in Cancer Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Science ; 380(6650): eadg0934, 2023 06 16.
Article em En | MEDLINE | ID: mdl-37319212
ABSTRACT
Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We characterized 163 distinct cell types and performed an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further developed aging clock models to predict fly age and show that ribosomal gene expression is a conserved predictive factor for age. Combining all aging features, we find distinctive cell type-specific aging patterns. This atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Senescência Celular / Drosophila melanogaster Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Senescência Celular / Drosophila melanogaster Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos