Properties and biotechnological applications of microbial deacetylase.
Appl Microbiol Biotechnol
; 107(15): 4697-4716, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37326683
ABSTRACT
Deacetylases, a class of enzymes that can catalyze the hydrolysis of acetylated substrates to remove the acetyl group, used in producing various products with high qualities, are one of the most influential industrial enzymes. These enzymes are highly specific, non-toxic, sustainable, and eco-friendly biocatalysts. Deacetylases and deacetylated compounds have been widely applicated in pharmaceuticals, medicine, food, and the environment. This review synthetically summarizes deacetylases' sources, characterizations, classifications, and applications. Moreover, the typical structural characteristics of deacetylases from different microbial sources are summarized. We also reviewed the deacetylase-catalyzed reactions for producing various deacetylated compounds, such as chitosan-oligosaccharide (COS), mycothiol, 7-aminocephalosporanic acid (7-ACA), glucosamines, amino acids, and polyamines. It is aimed to expound on the advantages and challenges of deacetylases in industrial applications. Moreover, it also serves perspectives on obtaining promising and innovative biocatalysts for enzymatic deacetylation. KEYPOINTS ⢠The fundamental properties of microbial deacetylases of various microorganisms are presented. ⢠The biochemical characterizations, structures, and catalyzation mechanisms of microbial deacetylases are summarized. ⢠The applications of microbial deacetylases in food, pharmaceutical, medicine, and the environment were discussed.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrólise
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Ano de publicação:
2023
Tipo de documento:
Article