Extracellular HSP90 warms up integrins for an irisin workout.

Bourboulia, Dimitra; Woodford, Mark R; Mollapour, Mehdi

Bourboulia, Dimitra; Woodford, Mark R; Mollapour, Mehdi.

Afiliação

Bourboulia D; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: bourmpod@upstate.edu.
Woodford MR; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: woodform@upstate.edu.
Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: mollapom@upstate.edu.

Cell Metab ; 35(7): 1099-1100, 2023 07 11.

Article em En | MEDLINE | ID: mdl-37327790

RESUMO

The hormone-like protein irisin is involved in browning of adipose tissue and regulation of metabolism. Recently, Mu et al. identified the extracellular chaperone heat shock protein-90 (Hsp90) as the activating factor for "opening" αVß5 integrin receptor, allowing for high-affinity irisin binding and effective signal transduction.

Assuntos

Fibronectinas; Integrinas; Fibronectinas/metabolismo; Transdução de Sinais; Tecido Adiposo/metabolismo; Proteínas de Choque Térmico HSP90/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Integrinas / Fibronectinas Tipo de estudo: Prognostic_studies Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2023 Tipo de documento: Article

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