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Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Gaynor, Katherine U; Vaysburd, Marina; Harman, Maximilian A J; Albecka, Anna; Jeffrey, Phillip; Beswick, Paul; Papa, Guido; Chen, Liuhong; Mallery, Donna; McGuinness, Brian; Van Rietschoten, Katerine; Stanway, Steven; Brear, Paul; Lulla, Aleksei; Ciazynska, Katarzyna; Chang, Veronica T; Sharp, Jo; Neary, Megan; Box, Helen; Herriott, Jo; Kijak, Edyta; Tatham, Lee; Bentley, Eleanor G; Sharma, Parul; Kirby, Adam; Han, Ximeng; Stewart, James P; Owen, Andrew; Briggs, John A G; Hyvönen, Marko; Skynner, Michael J; James, Leo C.
Afiliação
  • Gaynor KU; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Vaysburd M; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Harman MAJ; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Albecka A; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Jeffrey P; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Beswick P; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Papa G; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Chen L; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Mallery D; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • McGuinness B; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Van Rietschoten K; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Stanway S; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
  • Brear P; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
  • Lulla A; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
  • Ciazynska K; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Chang VT; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Sharp J; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Neary M; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Box H; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Herriott J; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Kijak E; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Tatham L; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Bentley EG; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Sharma P; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Kirby A; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Han X; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Stewart JP; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Owen A; University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdom.
  • Briggs JAG; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, United Kingdom.
  • Hyvönen M; Max Planck Institute of Biochemistry, Martinsried, 82152, Germany.
  • Skynner MJ; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
  • James LC; Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom. michael.skynner@bicycletx.com.
Nat Commun ; 14(1): 3583, 2023 06 16.
Article em En | MEDLINE | ID: mdl-37328472
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido