Entry of microparticles into giant lipid vesicles by optical tweezers.
Phys Rev E
; 107(5): L052601, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37328973
ABSTRACT
Entry of micro- or nanosized objects into cells or vesicles made of lipid membranes occurs in many processes such as entry of viruses into host cells, microplastics pollution, drug delivery, or biomedical imaging. Here we investigate the microparticle crossing of lipid membranes in giant unilamellar vesicles in the absence of strong binding interactions (e.g., streptavidin-biotin binding). In these conditions, we observe that organic and inorganic particles can always penetrate inside the vesicles provided an external piconewton force is applied and for relatively low membrane tensions. In the limit of vanishing adhesion, we identify the role of the membrane area reservoir and show that a force minimum exists when the particle size is comparable to the bendocapillary length.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plásticos
/
Pinças Ópticas
Idioma:
En
Revista:
Phys Rev E
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França