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Accumulative Rolling Mg/PLLA Composite Membrane with Lamellar Heterostructure for Enhanced Bacteria Inhibition and Rapid Bone Regeneration.
Wang, Xianli; Qian, Yuxin; Wang, Shuang; Wang, Mingxi; Sun, Ke; Cheng, Zhaojun; Shao, Yi; Zhang, Shixuan; Tang, Chunbo; Chu, Chenglin; Xue, Feng; Tao, Li; Lu, Mengmeng; Bai, Jing.
Afiliação
  • Wang X; School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing, Jiangsu, 211189, China.
  • Qian Y; Jiangsu Key Laboratory for Advanced Metallic Materials, Jiangning, Nanjing, Jiangsu,  211189,  China.
  • Wang S; Institute of Medical Devices (Suzhou), Southeast University, Suzhou, 215000,  China.
  • Wang M; Department of Oral Implantology, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029,  China.
  • Sun K; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029,  China.
  • Cheng Z; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing,  210029,  China.
  • Shao Y; Department of Oral Implantology, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029,  China.
  • Zhang S; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029,  China.
  • Tang C; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing,  210029,  China.
  • Chu C; Department of Oral Implantology, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029,  China.
  • Xue F; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029,  China.
  • Tao L; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing,  210029,  China.
  • Lu M; School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing, Jiangsu, 211189, China.
  • Bai J; Jiangsu Key Laboratory for Advanced Metallic Materials, Jiangning, Nanjing, Jiangsu,  211189,  China.
Small ; 19(42): e2301638, 2023 10.
Article em En | MEDLINE | ID: mdl-37345962
ABSTRACT
Developing composite materials with optimized mechanics, degradation, and bioactivity for bone regeneration has long been a crucial mission. Herein, a multifunctional Mg/Poly-l-lactic acid (Mg/PLLA) composite membrane based on the "materials plain" concept through the accumulative rolling (AR) method is proposed. Results show that at a rolling ratio of 75%, the comprehensive mechanical properties of the membrane in the rolling direction are self-reinforced significantly (elongation at break ≈53.2%, tensile strength ≈104.0 MPa, Young's modulus ≈2.13 GPa). This enhancement is attributed to the directional arrangement and increased crystallization of PLLA molecular chains, as demonstrated by SAXS and DSC results. Furthermore, the AR composite membrane presents a lamellar heterostructure, which not only avoids the accumulation of Mg microparticles (MgMPs) but also regulates the degradation rate. Through the contribution of bioactive MgMPs and their photothermal effect synergistically, the membrane effectively eliminates bacterial infection and accelerates vascularized bone regeneration both in vitro and in vivo. Notably, the membrane exhibits outstanding rat skull bone regeneration performance in only 4 weeks, surpassing most literature reports. In short, this work develops a composite membrane with a "one stone, four birds" effect, opening an efficient avenue toward high-performance orthopedic materials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Regeneração Óssea Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Regeneração Óssea Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China