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Diabetes-related perturbations in the integrity of physiologic barriers.
Mooradian, Arshag D.
Afiliação
  • Mooradian AD; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL, USA. Electronic address: arshag.mooradian@jax.ufl.edu.
J Diabetes Complications ; 37(8): 108552, 2023 08.
Article em En | MEDLINE | ID: mdl-37356233
One of the hallmarks of health is the integrity of barriers at the cellular and tissue levels. The two cardinal functions of barriers include preventing access of deleterious elements of the environment (barrier function) while facilitating the transport of essential ions, signaling molecules and nutrients needed to maintain the internal milieu (transport function). There are several cellular and subcellular barriers and some of these barriers can be interrelated. The principal physiologic barriers include blood-retinal barrier, blood-brain barrier, blood-testis barrier, renal glomerular/tubular barrier, intestinal barrier, pulmonary blood-alveolar barrier, blood-placental barrier and skin barrier. Tissue specific barriers are the result of the vasculature, cellular composition of the tissue and extracellular matrix within the tissue. Uncontrolled diabetes and acute hyperglycemia may disrupt the integrity of physiologic barriers, primarily through altering the vascular integrity of the tissues and may well contribute to the clinically recognized complications of diabetes. Although diabetes is a systemic disease, some of the organs display clinically significant deterioration in function while others undergo subclinical changes. The pathophysiology of the disruption of these barriers is not entirely clear but it may be related to diabetes-related cellular stress. Understanding the mechanisms of diabetes related dysfunction of various physiologic barriers might help identifying novel therapeutic targets for reducing clinically significant complications of diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações do Diabetes / Diabetes Mellitus / Hiperglicemia Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Diabetes Complications Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações do Diabetes / Diabetes Mellitus / Hiperglicemia Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Diabetes Complications Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article