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The anterior insular cortex processes social recognition memory.
Min, Ji-You; Park, Sanggeon; Cho, Jeiwon; Huh, Yeowool.
Afiliação
  • Min JY; Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Park S; Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Cho J; Brain Disease Research Institute, Ewha Brain Institute, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Huh Y; Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, 03760, Republic of Korea. jelectro21@ewha.ac.kr.
Sci Rep ; 13(1): 10853, 2023 07 05.
Article em En | MEDLINE | ID: mdl-37407809
ABSTRACT
Impaired social abilities are characteristics of a variety of psychiatric disorders such as schizophrenia, autism spectrum disorder, and bipolar disorder. Studies consistently implicated the relationship between the anterior insular cortex (aIC) and social ability, however, how the aIC involves in processing specific subtypes of social ability was uninvestigated. We, therefore, investigated whether the absence or presence of the aIC affects the social behaviors of mice. We found that electrolytic lesions of the aIC specifically impaired mice's ability to recognize a novel stranger mouse, while the sociability of the aIC-lesioned mice was intact. Interestingly, the aIC-lesioned mice were still distinguished between a mouse that had been housed together before the aIC lesion and a novel mouse, supporting that retrieval of social recognition memory may not involve the aIC. Additional behavioral tests revealed that this specific social ability impairment induced by the aIC lesion was not due to impairment in olfaction, learning and memory, locomotion, or anxiety levels. Together our data suggest that the aIC is specifically involved in processing social recognition memory, but not necessarily involved in retrieving it.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista / Córtex Insular Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Espectro Autista / Córtex Insular Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article