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Successful transplantation of LUCAS device assisted uncontrolled DCD kidneys with prolonged relative warm ischemia time: An underutilized option in North America.
Nagaraju, Santosh; Savilla, Rachel; Moore, Myla; Jones, Alice; Africa, Joseph.
Afiliação
  • Nagaraju S; Renal Transplant Program, Charleston Area Medical Center, Charleston, West Virginia, USA.
  • Savilla R; Renal Transplant Program, Charleston Area Medical Center, Charleston, West Virginia, USA.
  • Moore M; Renal Transplant Program, Charleston Area Medical Center, Charleston, West Virginia, USA.
  • Jones A; Renal Transplant Program, Charleston Area Medical Center, Charleston, West Virginia, USA.
  • Africa J; Renal Transplant Program, Charleston Area Medical Center, Charleston, West Virginia, USA.
Clin Transplant ; 37(8): e15058, 2023 08.
Article em En | MEDLINE | ID: mdl-37421597
ABSTRACT
Approximately 25% of deceased donors in the United States are procured in a donation after circulatory death (DCD) setting. Successful transplant outcomes from uncontrolled DCD (uDCD) practices have been reported in multiple European programs. They utilize established protocols for uDCD procurement with normo-thermic or hypothermic regional perfusion to reduce ischemic damage. Further, manual or mechanical chest compressions using extrinsic devices, such as the LUCAS device, are implemented to maintain circulation before organ retrieval. Currently, uDCDs are not a major part of DCD organ utilization in the United States. We report our experience with utilization of kidneys from uDCD with the use of the LUCAS device without normothermic or hypothermic regional perfusion. We transplanted four kidneys from three uDCD donors without utilization of in situ regional perfusion and with prolonged relative warm ischemia time (rWIT) (>100 min). All recipients had functional renal allografts and improved renal function after the transplant. To our knowledge, this is the 1st successful series reported in the United States of the utilization of kidneys from uDCDs without the utilization of in situ perfusion to maintain organ preservation with prolonged rWIT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obtenção de Tecidos e Órgãos / Transplante de Rim Tipo de estudo: Guideline Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Clin Transplant Assunto da revista: TRANSPLANTE Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obtenção de Tecidos e Órgãos / Transplante de Rim Tipo de estudo: Guideline Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Clin Transplant Assunto da revista: TRANSPLANTE Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos