Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors.

Vlachodimou, Anna; Bouma, Jara; De Cleyn, Michel; Berthelot, Didier; Pype, Stefan; Bosmans, Jean-Paul; van Vlijmen, Herman; Wroblowski, Berthold; Heitman, Laura H; IJzerman, Adriaan P

Vlachodimou, Anna; Bouma, Jara; De Cleyn, Michel; Berthelot, Didier; Pype, Stefan; Bosmans, Jean-Paul; van Vlijmen, Herman; Wroblowski, Berthold; Heitman, Laura H; IJzerman, Adriaan P.

Afiliação

Vlachodimou A; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
Bouma J; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
De Cleyn M; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Berthelot D; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Pype S; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Bosmans JP; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
van Vlijmen H; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
Wroblowski B; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Heitman LH; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

Purinergic Signal ; 20(2): 193-205, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37423967

Assuntos

Transportador Equilibrativo 1 de Nucleosídeo; Tioinosina; Humanos; Transporte Biológico; Tioinosina/metabolismo; Tioinosina/farmacologia; Transportador Equilibrativo 1 de Nucleosídeo/química; Transportador Equilibrativo 1 de Nucleosídeo/metabolismo

Palavras-chave

(Human) nucleoside transport protein (hENT1; Adenosine; Radioligand binding experiments; SLC29A1); Target binding kinetics; Transport inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioinosina / Transportador Equilibrativo 1 de Nucleosídeo Limite: Humans Idioma: En Revista: Purinergic Signal Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda

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