Acute generalized exanthematous pustulosis associated with clindamycin in a patient with Hailey-Hailey disease.
J Cutan Pathol
; 50(10): 864-868, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37430411
ABSTRACT
A 61-year-old African-American female with moderately controlled Hailey-Hailey disease (HHD) presents to the emergency department with a rash and fever. One day prior to her presentation, she was started on oral clindamycin for a tooth extraction procedure. Her physical examination shows diffuse erythema on the trunk and extremities with multiple nonfollicular pustules. A punch biopsy of her upper extremity revealed intraepidermal acantholysis, neutrophilic spongiosis, and subcorneal pustules. The perivascular and interstitial superficial dermal infiltrate is mixed and composed of predominantly neutrophils, with lymphocytes and rare eosinophils. These findings suggest a superimposed acute generalized exanthematous pustulosis (AGEP) in the background of HHD. AGEP is a potentially severe cutaneous condition characterized by the abrupt onset of numerous nonfollicular pustules in a background of pruritic edematous erythroderma. To date, only two case reports have described AGEP in patients with HHD. Early diagnosis of AGEP is essential to initiate prompt and aggressive systemic therapy, prompt medication cessation, close monitoring for end-organ damage, and improve overall morbidity and mortality.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pênfigo Familiar Benigno
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Exantema
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Pustulose Exantematosa Aguda Generalizada
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
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Screening_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos