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Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study.
Pessôa, Rodrigo; de Souza, Daniela Raguer Valadão; Nukui, Youko; Pereira, Juliana; Fernandes, Lorena Abreu; Marcusso, Rosa Nascimento; de Oliveira, Augusto César Penalva; Casseb, Jorge; da Silva Duarte, Alberto José; Sanabani, Sabri Saeed.
Afiliação
  • Pessôa R; Postgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.
  • de Souza DRV; Postgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.
  • Nukui Y; Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Pereira J; Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
  • Fernandes LA; Postgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.
  • Marcusso RN; Department of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.
  • de Oliveira ACP; Department of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.
  • Casseb J; Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
  • da Silva Duarte AJ; Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
  • Sanabani SS; Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Int J Mol Sci ; 24(13)2023 Jun 26.
Article em En | MEDLINE | ID: mdl-37445821
ABSTRACT
Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Linfotrópico T Tipo 1 Humano / Leucemia-Linfoma de Células T do Adulto / Linfoma Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Linfotrópico T Tipo 1 Humano / Leucemia-Linfoma de Células T do Adulto / Linfoma Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil