Advances in understanding the role of dendritic cells in aplastic anaemia.
Scand J Immunol
; 97(5): e13265, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37489592
ABSTRACT
Aplastic anaemia (AA) is an autoimmune disease characterized by haematopoietic failure in the bone marrow. Abnormal activation and hyperfunction of T lymphocytes are believed to cause bone marrow damage, which plays a major role in AA pathogenesis. Dendritic cells (DCs) play a vital role in the immune system by processing antigens for presentation to T cells and regulating their differentiation and function. DC dysfunction may cause abnormal T-cell activation. Recent studies have associated the occurrence and development of AA with DC function. In this review, we have discussed the role of DCs in AA pathogenesis and their potential as putative therapeutic targets for AA.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Anemia Aplástica
Limite:
Humans
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China