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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano, Anna; Silvestre, Margaux; Wells, Carrow I; Sanderson, Jennifer L; Ferrer, Carla A; Ong, Han Wee; Lang, Yi; Richardson, William; Silvaroli, Josie A; Bashore, Frances M; Smith, Jeffery L; Genereux, Isabelle M; Dempster, Kelvin; Drewry, David H; Pabla, Navlot S; Bullock, Alex N; Benke, Tim A; Ultanir, Sila K; Axtman, Alison D.
Afiliação
  • Castano A; Department of Pharmacology, University of Colorado School of Medicine, Aurora, United States.
  • Silvestre M; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.
  • Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Sanderson JL; Department of Pharmacology, University of Colorado School of Medicine, Aurora, United States.
  • Ferrer CA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Ong HW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Lang Y; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Richardson W; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Silvaroli JA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States.
  • Bashore FM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Smith JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Genereux IM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Dempster K; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.
  • Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Pabla NS; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
  • Bullock AN; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States.
  • Benke TA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Ultanir SK; Departments of Pediatrics, Pharmacology, Neurology and Otolaryngology, University of Colorado School of Medicine, Aurora, United States.
  • Axtman AD; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom.
Elife ; 122023 07 25.
Article em En | MEDLINE | ID: mdl-37490324
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Hipocampo Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Hipocampo Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos