In vivo and In silico evidence of the protective properties of carvacrol against experimentally-induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and antiapoptotic mechanisms.

Badr, Amira M; El-Orabi, Naglaa F; Mahran, Yasmen F; Badr, Amul M; Bayoumy, Nervana Mustafa; Hagar, Hanan; Elmongy, Elshaymaa I; Atawia, Reem T

Badr, Amira M; El-Orabi, Naglaa F; Mahran, Yasmen F; Badr, Amul M; Bayoumy, Nervana Mustafa; Hagar, Hanan; Elmongy, Elshaymaa I; Atawia, Reem T.

Afiliação

Badr AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
El-Orabi NF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Mahran YF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt.
Badr AM; Department of Medical Biochemistry and Molecular Biology, Kasr Al-Aini Faculty of Medicine, Cairo University, Egypt.
Bayoumy NM; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Hagar H; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Elmongy EI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.
Atawia RT; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, United States. Electronic address: reemtarekatawia@pharma.asu.edu.eg.

Chem Biol Interact ; 382: 110649, 2023 Sep 01.

Article em En | MEDLINE | ID: mdl-37499997

Assuntos

Antiulcerosos; Úlcera Gástrica; Ratos; Animais; Antioxidantes/metabolismo; Úlcera Gástrica/induzido quimicamente; Úlcera Gástrica/tratamento farmacológico; Úlcera Gástrica/prevenção & controle; Fator de Necrose Tumoral alfa/metabolismo; Úlcera/tratamento farmacológico; Úlcera/metabolismo; Úlcera/patologia; Anti-Inflamatórios/efeitos adversos; Estresse Oxidativo; Antiulcerosos/farmacologia; Glutationa Peroxidase/metabolismo; Etanol/metabolismo; Mucinas/metabolismo; Mucinas/farmacologia; Mucinas/uso terapêutico; Mucosa Gástrica

Palavras-chave

Apoptosis; Carvacrol; Ethanol; Gastric ulcer; Inflammation; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Úlcera Gástrica / Antiulcerosos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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