Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies.

Muhammad, Shan; Fan, Tao; Hai, Yang; Gao, Yibo; He, Jie

Muhammad, Shan; Fan, Tao; Hai, Yang; Gao, Yibo; He, Jie.

Afiliação

Muhammad S; Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Fan T; Laboratory of Translational Medicine, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Hai Y; Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Gao Y; Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
He J; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Mol Cancer ; 22(1): 121, 2023 07 29.

Article em En | MEDLINE | ID: mdl-37516849

Assuntos

Interleucina-2; Neoplasias; Humanos; Interleucina-2/genética; Interleucina-2/uso terapêutico; Neoplasias/tratamento farmacológico; Neoplasias/genética; Carcinogênese; Imunoterapia; Ciclo Celular; Microambiente Tumoral

Palavras-chave

Cancer biomarkers; Cancer immunosurveillance; Cancer prognosis and IL-2; Checkpoint inhibitors; Combination cancer therapy; Dose optimization of IL-2; Engineered IL-2 variants; IL-2 receptor (IL-2R); IL-2-based immunotherapy; Immune activation and tolerance; Interleukin-2 (IL-2); Personalized cancer treatment; Regulatory T cells; Tumor immune response; Tumor microenvironment; Tumorigenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-2 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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